Sequential treatment with quinine and mefloquine or quinine and pyrimethamine-sulfadoxine for falciparum malaria.
Identifieur interne : 003953 ( Main/Exploration ); précédent : 003952; suivant : 003954Sequential treatment with quinine and mefloquine or quinine and pyrimethamine-sulfadoxine for falciparum malaria.
Auteurs : A P Hall ; E B Doberstyn ; C. Karnchanachetanee ; S. Samransamruajkit ; B. Laixuthai ; E J Pearlman ; R M Lampe ; C F Miller ; P. PhintuyothinSource :
- British Medical Journal [ 0007-1447 ] ; 1977-06-25.
English descriptors
- Teeft :
- Acta medica scandinavica, American journal, Apnoeic attacks, Asexual parasitaemia, Asexual parasites, Bacillus, Bacillus cereus, Clinical nutrition, Clinical picture, Cure rate, Diabetes mellitus, Dos, Effective treatment, Faecal streptococci, Falciparum, Falciparum malaria, Fansidar, Internal medicine, Last dose, Malaria, Medical clinics, Mefloquine, Moderate numbers, Numerous bacilli, Parasitaemia, Parasite, Parasite density, Quinine, Quinine base, Radical cure, Recrudescence, Regimen, Sequential, Sequential regimens, Sequential treatment, Severe falciparum malaria, Short course, Side effects, Single dose, Small numbers, Standard dose, Tropical medicine, World health organisation.
Abstract
Patients with falciparum malaria were studied in Thailand, an area of known chloroquine resistance. The patients were unselected and some had severe malaria, and they were randomly assigned to one of two sequential regimes. A short course of quinine (average 4 doses, equivalent to 2 g base) followed by a single dose of pyrimethamine-sulfadoxine (Fansidar) cured 92% of patients (36 out of 39), while a short course of quinine followed by a single 1-5-dose of mefloquine cured all of the 35 patients who could be followed up. Gastrointestinal side effects were minimal if at least 12 hours elapsed between the last dose of quinine and the mefloquine. Sequential quinine and mefloquine is the most effective treatment for patients with chloroquine-resistant falciparum malaria, including those with severe or complicated disease. Mefloquine, however, is not commercially available, and the similar regimen using Fansidar is almost as effective.
Url:
DOI: 10.1136/bmj.1.6077.1626
Affiliations:
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Phintuyothin</name></author></analytic><monogr></monogr><series><title level="j">British Medical Journal</title><title level="j" type="abbrev">Br Med J</title><idno type="ISSN">0007-1447</idno><idno type="eISSN">1468-5833</idno><imprint><publisher>British Medical Journal Publishing Group</publisher><date type="published" when="1977-06-25">1977-06-25</date><biblScope unit="volume">1</biblScope><biblScope unit="issue">6077</biblScope><biblScope unit="page" from="1626">1626</biblScope></imprint><idno type="ISSN">0007-1447</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0007-1447</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acta medica scandinavica</term><term>American journal</term><term>Apnoeic attacks</term><term>Asexual parasitaemia</term><term>Asexual parasites</term><term>Bacillus</term><term>Bacillus cereus</term><term>Clinical nutrition</term><term>Clinical picture</term><term>Cure rate</term><term>Diabetes mellitus</term><term>Dos</term><term>Effective treatment</term><term>Faecal streptococci</term><term>Falciparum</term><term>Falciparum malaria</term><term>Fansidar</term><term>Internal medicine</term><term>Last dose</term><term>Malaria</term><term>Medical clinics</term><term>Mefloquine</term><term>Moderate numbers</term><term>Numerous bacilli</term><term>Parasitaemia</term><term>Parasite</term><term>Parasite density</term><term>Quinine</term><term>Quinine base</term><term>Radical cure</term><term>Recrudescence</term><term>Regimen</term><term>Sequential</term><term>Sequential regimens</term><term>Sequential treatment</term><term>Severe falciparum malaria</term><term>Short course</term><term>Side effects</term><term>Single dose</term><term>Small numbers</term><term>Standard dose</term><term>Tropical medicine</term><term>World health organisation</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patients with falciparum malaria were studied in Thailand, an area of known chloroquine resistance. The patients were unselected and some had severe malaria, and they were randomly assigned to one of two sequential regimes. A short course of quinine (average 4 doses, equivalent to 2 g base) followed by a single dose of pyrimethamine-sulfadoxine (Fansidar) cured 92% of patients (36 out of 39), while a short course of quinine followed by a single 1-5-dose of mefloquine cured all of the 35 patients who could be followed up. Gastrointestinal side effects were minimal if at least 12 hours elapsed between the last dose of quinine and the mefloquine. Sequential quinine and mefloquine is the most effective treatment for patients with chloroquine-resistant falciparum malaria, including those with severe or complicated disease. Mefloquine, however, is not commercially available, and the similar regimen using Fansidar is almost as effective.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Doberstyn, E B" sort="Doberstyn, E B" uniqKey="Doberstyn E" first="E B" last="Doberstyn">E B Doberstyn</name><name sortKey="Hall, A P" sort="Hall, A P" uniqKey="Hall A" first="A P" last="Hall">A P Hall</name><name sortKey="Karnchanachetanee, C" sort="Karnchanachetanee, C" uniqKey="Karnchanachetanee C" first="C" last="Karnchanachetanee">C. Karnchanachetanee</name><name sortKey="Laixuthai, B" sort="Laixuthai, B" uniqKey="Laixuthai B" first="B" last="Laixuthai">B. Laixuthai</name><name sortKey="Lampe, R M" sort="Lampe, R M" uniqKey="Lampe R" first="R M" last="Lampe">R M Lampe</name><name sortKey="Miller, C F" sort="Miller, C F" uniqKey="Miller C" first="C F" last="Miller">C F Miller</name><name sortKey="Pearlman, E J" sort="Pearlman, E J" uniqKey="Pearlman E" first="E J" last="Pearlman">E J Pearlman</name><name sortKey="Phintuyothin, P" sort="Phintuyothin, P" uniqKey="Phintuyothin P" first="P" last="Phintuyothin">P. Phintuyothin</name><name sortKey="Samransamruajkit, S" sort="Samransamruajkit, S" uniqKey="Samransamruajkit S" first="S" last="Samransamruajkit">S. Samransamruajkit</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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